{"id":1634,"date":"2017-06-07T14:17:40","date_gmt":"2017-06-07T14:17:40","guid":{"rendered":"https:\/\/cancer.wisc.edu\/research\/?p=1634"},"modified":"2018-05-17T09:24:27","modified_gmt":"2018-05-17T14:24:27","slug":"metabolic-priming-for-breast-cancer","status":"publish","type":"post","link":"https:\/\/wwwtest.cancer.wisc.edu\/research\/metabolic-priming-for-breast-cancer\/","title":{"rendered":"Metabolic Priming for Breast Cancer"},"content":{"rendered":"<p>Dr. Ruth O\u2019Regan and Dr. Vincent Cryns have teamed up to translate their lab discovery of metabolic priming into a clinical trial in patients with metastatic triple-negative breast cancer. They use a diet low in an essential nutrient methionine to prime the tumor cells to respond better to drugs that activate cell death.<\/p>\n<p>WON will enable the research team to recruit patients throughout the state of Wisconsin and increase impact beyond Madison.<\/p>\n<p><strong>Upcoming trials<\/strong><\/p>\n<p>Drs. O&#8217;Regan and Cryns have received funding from the V Foundation for Cancer Research and the Wisconsin Partnership Program for a phase II trial of a novel targeted agent (ONC201) that activates cell death in metastatic triple-negative breast cancer. ONC201 will be given alone or in combination with a low methionine diet. The diet will consist of a medical food that lacks methionine and fruits and vegetables that are low in methionine.<\/p>\n<p>This funded WON trial is still under IRB review and has not opened to accrual yet.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Ruth O\u2019Regan and Dr. Vincent Cryns have teamed up to translate their lab discovery of metabolic priming into a clinical trial in patients with metastatic triple-negative breast cancer. They use a diet low in &hellip;<\/p>\n","protected":false},"author":1,"featured_media":1609,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0},"categories":[10],"tags":[45,43,44,48,47,42,51,46,49,50,11],"acf":[],"_links":{"self":[{"href":"https:\/\/wwwtest.cancer.wisc.edu\/research\/wp-json\/wp\/v2\/posts\/1634"}],"collection":[{"href":"https:\/\/wwwtest.cancer.wisc.edu\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wwwtest.cancer.wisc.edu\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wwwtest.cancer.wisc.edu\/research\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wwwtest.cancer.wisc.edu\/research\/wp-json\/wp\/v2\/comments?post=1634"}],"version-history":[{"count":6,"href":"https:\/\/wwwtest.cancer.wisc.edu\/research\/wp-json\/wp\/v2\/posts\/1634\/revisions"}],"predecessor-version":[{"id":6739,"href":"https:\/\/wwwtest.cancer.wisc.edu\/research\/wp-json\/wp\/v2\/posts\/1634\/revisions\/6739"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/wwwtest.cancer.wisc.edu\/research\/wp-json\/wp\/v2\/media\/1609"}],"wp:attachment":[{"href":"https:\/\/wwwtest.cancer.wisc.edu\/research\/wp-json\/wp\/v2\/media?parent=1634"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wwwtest.cancer.wisc.edu\/research\/wp-json\/wp\/v2\/categories?post=1634"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wwwtest.cancer.wisc.edu\/research\/wp-json\/wp\/v2\/tags?post=1634"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}