{"id":10135,"date":"2019-02-06T14:03:19","date_gmt":"2019-02-06T20:03:19","guid":{"rendered":"https:\/\/cancer.wisc.edu\/research\/?p=10135"},"modified":"2019-05-30T15:35:17","modified_gmt":"2019-05-30T20:35:17","slug":"new-equipment-shimadzu-hplc","status":"publish","type":"post","link":"https:\/\/wwwtest.cancer.wisc.edu\/research\/new-equipment-shimadzu-hplc\/","title":{"rendered":"New Equipment: Shimadzu HPLC for PK\/PD"},"content":{"rendered":"<p>The Cancer Pharmacology Lab (CPL) recently acquired a new Shimadzu high performance liquid chromatography (HPLC) instrument, boosting their capacity to run pharmacokinetic\/pharmacodynamic analyses!\u00a0 The new instrument features an SPD-M20A Diode Array Detector module, allowing it to simultaneously measure a range of wavelengths and compare signal across all of them, while still maintaining a sensitivity comparable to the most advanced UV-Vis detectors. CPL just completed their first analysis on the new instrument, a measurement of the capecitabine metabolites 5\u2019-Fluorouracil (5FU), 5\u2019-Deoxy-5\u2019Fluorocytidine (DFCR), and 5\u2019-Deoxy-5\u2019Fluorouridine (DFUR), and is ramping up to run a pharmacokinetic analysis of the novel PARP inhibitor talazoparib in human plasma. \u00a0Contact <a href=\"mailto:geananiev@wisc.edu\">Gene Ananiev<\/a> if you have a need for pharmacokinetic \/ pharmacodynamic analysis in your research project.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Cancer Pharmacology Lab (CPL) recently acquired a new Shimadzu high performance liquid chromatography (HPLC) instrument, boosting their capacity to run pharmacokinetic\/pharmacodynamic analyses!\u00a0 The new instrument features an SPD-M20A Diode Array Detector module, allowing it &hellip;<\/p>\n","protected":false},"author":31,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0},"categories":[155,16],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/wwwtest.cancer.wisc.edu\/research\/wp-json\/wp\/v2\/posts\/10135"}],"collection":[{"href":"https:\/\/wwwtest.cancer.wisc.edu\/research\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wwwtest.cancer.wisc.edu\/research\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wwwtest.cancer.wisc.edu\/research\/wp-json\/wp\/v2\/users\/31"}],"replies":[{"embeddable":true,"href":"https:\/\/wwwtest.cancer.wisc.edu\/research\/wp-json\/wp\/v2\/comments?post=10135"}],"version-history":[{"count":5,"href":"https:\/\/wwwtest.cancer.wisc.edu\/research\/wp-json\/wp\/v2\/posts\/10135\/revisions"}],"predecessor-version":[{"id":10185,"href":"https:\/\/wwwtest.cancer.wisc.edu\/research\/wp-json\/wp\/v2\/posts\/10135\/revisions\/10185"}],"wp:attachment":[{"href":"https:\/\/wwwtest.cancer.wisc.edu\/research\/wp-json\/wp\/v2\/media?parent=10135"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wwwtest.cancer.wisc.edu\/research\/wp-json\/wp\/v2\/categories?post=10135"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wwwtest.cancer.wisc.edu\/research\/wp-json\/wp\/v2\/tags?post=10135"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}